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Talk by Hemmo Meyer

Title: "The endo-lysosomal damage response"
Occasion: SFB Seminar
Start: 30.05.2024 - 16:15
Location: CellNanOs, 38/201

About the speaker: Prof. Dr. Hemmo Meyer conducts research at the Center of Medical Biotechnology (ZMB), University of Duisburg-Essen.

Abstract of the talk: Lysosomes are the main degradative organelles of the cell and key signaling platforms. Lysosomal membrane permeabilization (LMP) or full rupture can be caused by many conditions and is relevant for neurodegeneration, infection and cancer. Depending on the extent of damage, lysosomes can either be repaired through various mechanisms or degraded by a form of selective autophagy termed lysophagy. I will present our data on how a complex pattern of ubiquitylation and a ubiquitin-effector, the AAA ATPase VCP/p97, coordinate the formation of the phagophore to drive efficient lysophagy of terminally damaged lysosomes. Moreover, I will present our data on the decision-making between repair and lysophagy which is governed by the sensor SPG20/Spartin that detects damage-associated lipid-packing defects and recruits the ubiquitin ligase ITCH to trigger lysophagy. In this context, the nature of lysosomal membrane permeabilization will be discussed.