Top content

Talk by Fabien Alpy

This presentation has been rescheduled for 05/20/2022, 10:30 am.

Title: "Touché! Formation, role and regulation of inter-organelle contacts"
Occasion: SFB Seminar
Host: Ayelén González Montoro
Start: 19.05.2022 - 16:15
Location: CellNanOs 38/201 

About the speaker: Fabien Alpy researches at the Institut de Génétique et de Biologie Moléculaire et Cellulaire in Illkirch, France.

Abstract of the talk: The endoplasmic reticulum (ER), a major membrane-bound organelle of eukaryotic cells, ensures diverse functions such as lipid synthesis, protein synthesis and folding, calcium storage, etc. The ER has a network architecture spreading throughout the cytosol, and is in physical contact with other organelles such as mitochondria, endosomes/lysosomes, autophagic structures, peroxisomes, lipid droplets, and the plasma membrane. These contacts, which do not lead to organelle fusion, are named membrane contact sites. They are scaffolded by protein bridges connecting the two membranes and involving protein–membrane and protein–protein interactions. Using ER-endosome and ER-lipid droplet contacts as examples, I will discuss how contacts are built, their role in lipid transport , and how they are regulated.