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Talk by Lukas Kapitein

Title: "Dissecting cellular organization and dynamics using super-resolution microscopy and optogenetics"
Occasion: SFB - Seminar
Start: 11.01.2024 - 16:15
Location: CellNanOs, 38/201

About the speaker: Prof. Dr. Lukas Kapitein conducts research about cell biology, neurobiology and biophysics at the Utecht University, The Netherlands.

Abstract of the talk: To explore cellular organization in health and disease our group develops and employs innovative light-based approaches, such as super-resolution microscopy and optogenetics. One of our ambitions is to dissect how the interplay between cytoskeletal organization and intracellular transport underlies the polarized morphology of neurons. In addition, we recently started studying how pathological aggregates alter cellular organization and dynamics. I will present our latest results in these two areas and show: 1/ how super-resolution and optogenetics enabled obtaining new insights into neuronal microtubule organization and dynamics, 2/ how pathological aggregates associated with Huntington’s Disease impair nuclear integrity by rupturing the nuclear envelope and hindering repair.