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Talk by Konstanze Winkelhofer

Title: "Linear ubiquitylation at the interface between protein quality control and innate immune signaling"
Occasion: SFB - Seminar
Start: 01.02.2024 - 16:15
Location: CellNanOs, 38/201

About the speaker: Prof. Dr. Winkelhofer conducts research at the Institure of Biochemistry and Pathobiochemistry of the Ruhr-Universität Bochum.

Abstract of the talk: Ubiquitylation is a multifaceted posttranslational modification, regulating a plethora of cellular processes. Its complexity is based on different variables, such as the number of ubiquitin molecules attached to substrates, the mode of inter-ubiquitin linkage, the formation of homo- and heterotypic chains, and the posttranslational modification of ubiquitin itself. We are particularly interested in M1-linked or linear ubiquitylation, which so far has mostly been studied in innate immune signaling. Our previous work revealed that the abundance of linear ubiquitin chains is regulated by genes that are linked to neurodegenerative diseases. From these studies a yet unknown function of linear ubiquitylation in protein quality control emerged. Linear ubiquitin chains together with their interacting protein NEMO remodel the interface of protein aggregates and thereby promote the local concentration of autophagy receptors, such as p62, for efficient autophagic degradation.